Lialda (Mesalamine)

Lialda (Mesalamine)


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LIALDA (Mesalamine) is a prescription medication prescribed to treat Crohn’s disease and Ulcerative Colitis. Both of these conditions fall under the term Inflammatory Bowel Disease (IBD).

IBD is a disease that affects the gastrointestinal tract, which includes the esophagus, stomach, small intestine, and large intestine. Crohn’s disease typically affects both the small and large intestines, while Ulcerative Colitis affects only the large intestine.

People with IBD have chronic inflammation in either the large intestine or both the large and small intestines. During inflammation, cells become swollen and enlarged, causing pain and reducing the ability of these organs to absorb nutrients from food. LIALDA blocks certain chemicals that intestinal cells use to signal inflammation, including cyclooxygenase and prostaglandins. By inhibiting these chemicals, LIALDA reduces inflammation for people with IBD and helps to treat and prevent symptoms.


The dose of LIALDA can vary based on what is being treated. Take LIALDA exactly as prescribed by your doctor.

The usual dosage is 2.4 g to 4.8 g once daily by mouth with food. The length of treatment is typically 8 weeks to induce remission.


The active ingredient in LIALDA is mesalamine.

LIALDA generic cannot always be interchanged with other brand names since they each contain different amounts of the active ingredient and were studied under different conditions. Speak with your doctor or pharmacist before switching brands.


Tell your doctor if you have a history of cardiovascular disease. Some patients have experienced myocarditis and pericarditis while taking LIALDA.

Some patients may experience acute intolerance syndrome that is difficult to distinguish from an IBD flare-up. Symptoms include abdominal pain, cramping, diarrhea, fever, headache, and rash. If you start taking LIALDA and experience a new onset of these symptoms, tell your doctor and you may need to stop LIALDA.

Side Effects

Some of the most common adverse reactions that people experience when they take LIALDA include:

  • Alopecia
  • Headache
  • Increase liver enzymes
  • Pancreatitis
  • Pruritus
  • Worsening of Ulcerative Colitis
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